valuation of origanum vulgare (leaves, stems and flowers) extract on spatial learning in male rats

introduction: origanum vulgare a rich source of natural phenolic antioxidants and has potential to be a source nutritional ingredients for functional food. herbs such as origanum have long been used in food preservation d in traditional medicine in the treatment of common ailments and have potential for positive modulation oxidation-linked diseases such as diabetes. here we investigated the effect of aqueous extract of origanum aves, stems and flowers) on spatial learning. methods: after scientific identification, the leaves were used for extraction. 35 adult nmri male rats weighing 0-350 gr were utilized in 5 groups. control group (no injection), the second group (saline injected), the extracts h different doses (150, 300, 450) mg/kg were injected intraperitoneally to experimental animals. all animals re trained for a spatial learning task using t-maze and were then trained subsequently daily based on standard thod. results: statistic analysis anova showed that origanum aqueous extract significantly decreased the number learning and error in simple and reverse learning (p<0.05) and it had no significant effect on delay time in both e of learning. conclusion: it can be concluded that the effect of origanum extract on learning can be due to its antioxidant d presence of anti acetylcholine estrase compounds such as ursolic acid.